hospitals in us

Oncotarget опубликовал « Метаболическое перепрограммирование клеток глиобластомы с помощью L-аспарагиназы, сенсибилизирует апоптоз in vitro и in vivo », в котором сообщается, что результаты предполагают, что некоторые культуры клеток глиомы особенно чувствительны к ингибированию пролиферации L-аспарагиназой, в то время как другие демонстрируют более устойчивую фенотип. В чувствительных клетках L-аспарагиназа вызывает апоптоз с диссипацией митохондриального мембранного потенциала и активацией эффекторных каспаз. Учитывая влияние L-аспарагиназы на эти молекулы, исследователи обнаружили, что L-аспарагиназа эффективно преодолевает устойчивость как к внутреннему апоптозу, индуцированному ингибитором Bcl-2 / Bcl-xL, ABT263, так и к внешнему апоптозу, опосредованному TRAIL, даже в клетках глиомы, которые устойчивы к однократной обработке L-аспарагиназой. In vivo комбинированное лечение ABT263 и L-аспарагиназой привело к усиленному снижению роста опухоли по сравнению с каждым реагентом по отдельности без индукции токсичности. Наблюдения в исследовании Oncotarget предполагают, что L-аспарагиназа может быть полезна для лечения злокачественных глиальных новообразований.

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hospitals in us

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When public refer to contemporary medicine, precision plays one of the most significant roles and human lives are directly dependent on it. Hereby, any researches related to medicine are necessary to meet the top standards. The problem today is that any recommendations of researches can be shared online and used as a reference without being adequately verified and approved. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this challenge and decided to generate an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been founded back in 2010. The key principle of this journal is related to Altmetric scores that are used as a quality measure. That helps both readers and authors to validate publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website provides a full publications list with corresponding scores higher than 100 as we...
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