hospitals in us

Oncotarget опубликовал « Метаболическое перепрограммирование клеток глиобластомы с помощью L-аспарагиназы, сенсибилизирует апоптоз in vitro и in vivo », в котором сообщается, что результаты предполагают, что некоторые культуры клеток глиомы особенно чувствительны к ингибированию пролиферации L-аспарагиназой, в то время как другие демонстрируют более устойчивую фенотип. В чувствительных клетках L-аспарагиназа вызывает апоптоз с диссипацией митохондриального мембранного потенциала и активацией эффекторных каспаз. Учитывая влияние L-аспарагиназы на эти молекулы, исследователи обнаружили, что L-аспарагиназа эффективно преодолевает устойчивость как к внутреннему апоптозу, индуцированному ингибитором Bcl-2 / Bcl-xL, ABT263, так и к внешнему апоптозу, опосредованному TRAIL, даже в клетках глиомы, которые устойчивы к однократной обработке L-аспарагиназой. In vivo комбинированное лечение ABT263 и L-аспарагиназой привело к усиленному снижению роста опухоли по сравнению с каждым реагентом по отдельности без индукции токсичности. Наблюдения в исследовании Oncotarget предполагают, что L-аспарагиназа может быть полезна для лечения злокачественных глиальных новообразований.

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hospitals in us

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